unicellular organism Get Printable Handwriting Hear It! Say It! Write It! Learn It! Spelling Test Definition noun. a living thing made up of one cell. Example Sentence A yeast is an example of a unicellular organism. More Example Sentences Some unicellular organisms can cause disease. Synonyms single-celled organism; microbe; bacterium Antonyms multicellular organism; complex organism; animal Hear It! Say It! Write It! unicellular organism Switch to cursive Start Share with your friends: