powderpuff Get Printable Handwriting Hear It! Say It! Write It! Learn It! Spelling Test Definition noun. a soft, fluffy ball used for applying powder or cosmetics Example Sentence She used a powderpuff to apply her makeup. Synonyms pompon; puffball; cosmetic puff Antonyms hardball; solid ball Hear It! Say It! Write It! powderpuff Switch to cursive Start Share with your friends: