extremophile Get Printable Handwriting Hear It! Say It! Write It! Learn It! Spelling Test Definition noun. a microorganism that lives in extreme environments Sentence: An extremophile was recently found on the outside of the space station. Example Sentence An extremophile was recently found on the outside of the space station. Synonyms durable; tough; survival Antonyms fragile Hear It! Say It! Write It! extremophile Switch to cursive Start Share with your friends: